Invitrogen™ EXOSC7 Recombinant Rabbit Monoclonal Antibody (JE55-72)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA542494

Product Code. 17719113

Description

Positive Control: K562 cell lysate, Jurkat cell lysate, U937 cell lysate, zebrafish tissue lysates, human colon carcinoma tissue, human esophagus tissue, human skin tissue, human prostate carcinoma tissue. Subcellular Location: Nucleus, Cytoplasm.

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Specifications

• Antigen: EXOSC7
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q15024
• Gene Symbols: EXOSC7
• Immunogen: Synthetic peptide within C-terminal Human RRP42.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Zebrafish
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: JE55-72
• Conjugate: Unconjugated
• Gene: EXOSC7
• Gene Alias: 2610002K22Rik; AV212732; EAP1; EGK_11725; EXOSC7; Exosome complex component RRP42; exosome complex exonuclease RRP42; exosome complex exonuclease RRP42; exosome complex component RRP42; Exosome complex exonuclease RRP42-like protein; exosome component 7; hRrp42p; hypothetical protein LOC550247; KIAA0116; mKIAA0116; p8; Ribosomal RNA-processing protein 42; RRP42; Rrp42p; zgc:110717
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 23016, 550247
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid