Invitrogen™ EXD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552218

Product Code. 15740171

Description

Immunogen sequence: TSCHAISNYY DNHLKQQLAK EFQAPIGSEE GLRLLEDPER RQVRSGARAL LNAESLPTQR KEELLQALRE FYNTDVVTEE MLQEAASLET RISNENYVPH GLKVVQCH Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%.

Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). [UniProt].

Specifications

• Antigen: EXD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EXD2
• Gene Alias: 3'-5' exoribonuclease EXD2; 4930539P14Rik; C14orf114; C85658; EXD2; EXDL2; exonuclease 3'-5' domain containing 2; exonuclease 3'-5' domain-containing protein 2; exonuclease 3''-5'' domain-like 2; exonuclease 3'-5' domain-like 2; exonuclease 3'-5' domain-like-containing protein 2; RGD1311087
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55218, 97827
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.80 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8VEG4, Q9NVH0
• Gene Symbols: EXD2
• Immunogen: Recombinant protein corresponding to Human EXD2. Recombinant protein control fragment (Product #RP-89042).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG