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EX 527

Product Code. 15426569
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10 mg
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Product Code. 15426569 Supplier Thermo Scientific Alfa Aesar Supplier No. J64753.MA
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Description

CAS: 49843-98-3 | C13H13ClN2O | 248.71 g/mol

EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 in
TRUSTED_SUSTAINABILITY

Specifications

CAS 49843-98-3
Color White
Molecular Formula C13H13ClN2O
MDL Number MFCD03009471
Quantity 10 mg
Synonym selisistat, sirt1 inhibitor iii, 1h-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro, 6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide, racemic, selisistat inn, 6-chloro-1,2,3,4,9-pentahydro-4ah-carbazolecarboxamide, ex-527 selisistat, ex 527 selisistat, d0e3lp, cambridge id 6859180
Solubility Information Soluble in dimethyl sulfoxide,ethanol and dimethyl formamide.
InChI Key FUZYTVDVLBBXDL-UHFFFAOYSA-N
SMILES C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
IUPAC Name 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Molecular Weight (g/mol) 248.71
PubChem CID 5113032
Formula Weight 248.71
Physical Form Powder
Chemical Name or Material EX 527
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