Invitrogen™ EWSR1 Monoclonal Antibody (5H7)

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
17815157	Invitrogen™ MA547354	500 μL
17875197	Invitrogen™ MA547453	100 μL

Description

EWSR1 Monoclonal Antibody for Western Blot, ICC/IF, IHC

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a ttranslocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Specifications

• Antigen: EWSR1
• Concentration: 1 mg/mL
• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: Q01844, Q61545
• Gene ID (Entrez): 100034010, 14030, 2130, 289752, 609786
• Immunogen: Full length human EWS expressed in and purified from <i>E. coli</i>.
• Product Type: Antibody

• Clone: 5H7
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2b
• Target Species: Human, Mouse, Rat, Canine, Horse
• Gene: EWSR1
• Gene Alias: AC002059.7; bK984G1.4; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma homolog; Ewings sarcoma EWS-Fli1 (type 1) oncogene; Ews; EWS oncogene; EWS RNA binding protein 1; EWS RNA-binding protein 1; EWS RNA-binding protein variant 6; EWS-FLI1; Ewsh; EWSR1; RNA-binding protein EWS
• Gene Symbols: EWSR1
• Primary or Secondary: Primary
• Purification Method: Protein A/G