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STEMCELL Technologies Everolimus
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Quantity:
10 mg
25 mg
Unit Size:
10mg
25mg
Description
- Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR)
- It is a hydroxyethyl ether-substituted derivative of rapamycin with improved pharmacokinetic and pharmacodynamic properties
- It inhibits both mTORC1 and mTORC2 complexes by binding to FK506-binding protein (FKBP-12), which then binds to mTOR, leading to complex destabilization and blocked kinase function (Zeng et al.; Lebwohl et al.; Sedrani et al.; Huang & Houghton)
- Inhibits cell proliferation, metabolism, and angiogenesis in a variety of cancers using in vitro and in vivo models (Zhu et al.; Lane et al.; O'Reilly et al.; Lebwohl et al.)
- Acts as an immunosuppressive agent in the context of organ transplantation (Lebwohl et al.; Wullschleger et al.)
Specifications
Specifications
| CAS | 159351-69-6 |
| Synonym | RAD001; SDZ-RAD; Xience |
| Quantity | 25 mg |
| Molecular Formula | C53H83NO14 |
| Purity | ≥95% |
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