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Invitrogen™ EVER2 Polyclonal Antibody

Product Code. 12858702
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Quantity:
100 μg
Unit Size:
100µg
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12858702 100 μg 100µg
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Product Code. 12858702 Supplier Invitrogen™ Supplier No. PA520526

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Jurkat cell lysate. PA5-20526 can be used with blocking peptide PEP-0646.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EVER2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TMC8
Gene Accession No. Q7TN58, Q8IU68
Gene Alias epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2; Epidermodysplasia verruciformis protein 2 homolog; EV2; Ever2; EVIN2; mFLJ00400; Tmc8; transmembrane channel like 8; transmembrane channel-like 8; transmembrane channel-like gene family 8; transmembrane channel-like protein 8
Gene Symbols TMC8
Host Species Rabbit
Immunogen A 14 amino acid peptide from near the center of human EVER2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147138, 217356, 688276
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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