ETS1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12118-1-AP-20UL

Product Code. 16819643

Description

Principal Names: c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54; Official Gene Symbol: ETS1 Gene ID: 2113 (Human) Gene Map Locus: 11q23.3 (Human) ETS1, a 441 A.A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependant IL-5 expression.

Specifications

• Antigen: ETS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ETS1
• Gene Alias: ETS 1, ETS1, EWSR2, p54, Protein C ets 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2113, 23871
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P14921, P27577
• Gene Symbols: ETS1
• Immunogen: ETS1 Fusion Protein Ag2127
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG