Invitrogen™ Estrogen Receptor beta (ER beta) ER Beta Recombinant Protein

Product Code. 15178156

Brand: Invitrogen™ A15664

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. ER beta full-length recombinant protein is: , Flexible—use in your in-house assay or as part of our PolarScreen™ ER Beta Competitive Binding Assay for a complete assay solution, Ready to use—active, purified, and native (untagged), Convenient—available in bulk sizes ER beta recombinant protein is manufactured under the strictest quality parameters. This product is guaranteed for 6 months after purchase. Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond. Protein Form: Recombinant, Full Length

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

Specifications

• Accession Number: Q92731
• Concentration: See Label
• For Use With (Application): Functional Assay
• Formulation: proprietary buffer with no preservative
• Gene ID (Entrez): 2100
• Molecular Weight (g/mol): 53.4 kDa
• Name: Estrogen Receptor beta (ER beta) ER Beta
• Quantity: 180 μg
• Regulatory Status: RUO - research use only
• Gene Alias: ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
• Common Name: Estrogen Receptor beta
• Protein Length: 477
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Expression System: Insect cells
• Form: Liquid