Invitrogen™ EphB4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596240

Product Code. 16539081

Description

Immunogen sequence: AVCQCRVGYF RARTDPRGAP CTTPPSAPRS VVSRLNGSSL HLEWSAPLES GGREDLTYAL RCRECRPGGS CAPCGGDLTF DPGPRDLVEP WVVVRGLRPD FTYTFEVTAL NGVSSLATGP VPFEPVNVTT DREVPPAVSD IRVTRSSPSS LSLAWAVPRA PSGAVLDYEV KYHEKGAEGP SSVRFLKTSE NRAELRGLKR GASYLVQVRA RSEAGYGPFG QEHHSQTQLD ESEGWREQLA L; Positive Samples: Mouse liver; Cellular Location: Cell membrane, Single-pass type I membrane protein.

EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Specifications

• Antigen: EphB4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPHB4
• Gene Alias: AI042935; Developmental kinase 2; EPH receptor B4; Ephb4; ephrin receptor EphB4; ephrin type-B receptor 4; Hepatoma transmembrane kinase; HTK; Mdk2; mDK-2; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13846, 2050
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.39 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P54760, P54761
• Gene Symbols: EPHB4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-540 of human EPHB4 (NP_0044353).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG