EphB1 (ephrin B1) Rat anti-Mouse, Clone: 25H11, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5300-80

25UG:ANTI-MOUSE EPHRIN B1 PURIFIED 25 UG

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15267407

Quantity Price
1 £ 82.0 / 25µg
Estimated Shipment date
from Supplier 08-12-2016
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Description and Specification

Specification

Antigen EphB1 (ephrin B1)
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Clone 25H11
Concentration 0.5mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias EFL-3, ELK ligand, EPH-related receptor tyrosine kinase ligand 2, LERK 2
Host Species Rat
Isotype IgG2a
Quantity 25μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody 25H11 recognizes mouse Ephrin B1, a 47kDa membrane protein. Ephrin B1 belongs to a family of ephrins composed of type A (linked to the cell membrane through a glycosylphosphatidyl inositol group) or type B (transmembrane) proteins. The type B ephrins consist of 3 members (B1, B2, and B3) each of which contains a cytoplasmic domain containing tyrosine residues that can be phosphorylated. Ephrin B and ephrin B receptors (Eph B) can interact to potentiate bidirectional downstream signaling between cells expressing either or both the ligand and receptor. Ephrins have been shown to play a role in neural crest cell development through both neurogenesis and neural migration, as well as development of kidney and heart cyto-architecture. Overexpression of type B ephrins in cancer cells is associated with increased vascularity and highly invasive tumors.