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Entrectinib, MedChemExpress

Product Code. 16497997
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Product Code. 16497997 Supplier Medchem Express Supplier No. HY12678

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Description

MedChemExpress Entrectinib (NMS-E628) is a potent, orally available, and CNS-active pan-Trk, ROS1, and ALK inhibitor. Entrectinib inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Antitumor activity.

Entrectinib (NMS-E628) is a potent, orally available, and CNS-active pan-Trk, ROS1, and ALK inhibitor. Entrectinib inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Antitumor activity.

Specifications

Chemical Name or Material Entrectinib
CAS 1108743-60-7
Color Off-White
Purity Grade Notes Research
Molecular Formula C31H34F2N6O2
Quantity 5 mg
Synonym NMS-E628 RXDX-101
Solubility Information DMSO : ≥ 31 mg/mL (55.29 mM)
SMILES O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6CCN(C)CC6)C=C4
Molecular Weight (g/mol) 560.64
Formula Weight 560.64
Percent Purity 98.13%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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