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Tocris Bioscience™ EMI 48
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Product Code. 18738446
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18738446

Brand: Tocris Bioscience™ 7424/10

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Description

Inhibitor of EGFR mutants

EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
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Specifications

Chemical Name or Material 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2 H-1-benzopyran-2-one
CAS 34564-13-1
Quantity 10 mg
Target EGF Receptor Inhibitors
Molecular Formula C21H20N2O3
Purity 0.98
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