Invitrogen™ eIF4E2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA534697

Product Code. 15318571

Description

Recommended positive controls: Target recombinant protein. Predicted reactivity: Mouse (97%), Zebrafish (91%), Dog (98%), Pig (98%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. [UniProt].

Specifications

• Antigen: eIF4E2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF4E2
• Gene Alias: 2700069E09Rik; 4EHP; 4E-LP; AI036339; AV129531; D0H0S6743E; EGK_04904; eIF4E type 2; eIF-4E type 2; Eif4e2; eIF4E-2; EIF4EL3; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; eukar; eukaryotic translation initiation factor 4E family member 2; eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E like 3; eukaryotic translation initiation factor 4E member 2; eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; h4EHP; IF4e; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 2; mRNA cap-binding protein type 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26987, 9470
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.36 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O60573, Q8BMB3
• Gene Symbols: EIF4E2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human EIF4E2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG