Invitrogen™ eIF3c Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA527527

Product Code. 13421637

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (93%), Xenopus laevis (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Specifications

• Antigen: eIF3c
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Eif3c
• Gene Alias: 110kDa; 3230401O13Rik; cell migration-inducing protein 17; eIF3 p110; eIF3 p110 {ECO:0000255; eIF3c; eIF3c {ECO:0000255; EIF3CL; eIF3-p110; EIF3S8; eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255; Eukaryotic translation initiation factor 3 subunit C; eukaryotic translation initiation factor 3 subunit C {ECO:0000255; eukaryotic translation initiation factor 3, subunit 8 (110 kDa); eukaryotic translation initiation factor 3, subunit 8 (110kD); eukaryotic translation initiation factor 3, subunit 8, 110kDa; eukaryotic translation initiation factor 3, subunit C; extra-toes spotting; HAMAP-Rule:MF_03002}; NIPIL(A3); NipilA3; NIPI-like protein; Xs; Xsl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8663
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.9 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q99613
• Gene Symbols: Eif3c
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human EIF3S8. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG