Invitrogen™ Human EIF2AK3 (PERK), GST Tag Recombinant Protein

Product Code. 15438703

Brand: Invitrogen™ PR8985A

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Specifications

• Accession Number: Q9NZJ5
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with 2mM DTT, 0.5mM EDTA, 50% glycerol, 0.02% Triton X-100, 150mM NaCl and no preservative; pH 7.5
• Gene ID (Entrez): 9451
• Molecular Weight (g/mol): 93.6 kDa
• Name: Human EIF2AK3 (PERK), GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 100 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
• Common Name: PERK
• Gene Symbol: EIF2AK3
• KinaseFamily: PEK Kinase Family
• Protein Length: 536-1116
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 536-1116
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Kinase Group: Ser⁄Thr Kinases: Other
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Catalytic
• Form: Liquid
• Research Category: Signal Transduction