Invitrogen™ EHD3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA570659

Product Code. 15899063

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

The EHD3 gene encodes the EH-domain containing protein 3, part of the EHD protein family involved in the regulation of endocytic recycling and membrane trafficking. EHD3 plays a crucial role in the endosomal transport system, impacting how receptors and other membrane proteins are recycled back to the cell surface after internalization. This protein aids in maintaining cellular homeostasis by ensuring the efficient sorting and transport of cargo through the endosomal system. EHD3 has been implicated in various cellular functions, including insulin signaling, receptor recycling, and neuronal development, and significantly influences synaptic transmission and plasticity. Alterations in EHD3 expression or function can disrupt endosomal trafficking processes and are linked to conditions such as neurodegenerative diseases and cancer. Research on EHD3 is focused on uncovering its role in membrane dynamics and identifying potential therapeutic strategies for disorders involving dysfunctional endocytic pathways.

Specifications

• Antigen: EHD3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EHD3
• Gene Alias: EH domain containing 3; EH domain-containing protein 3; Ehd2; Ehd3; EH-domain containing 3; EH-domain containing protein 2; PAST homolog 3; PAST3; si:ch211-147c1.2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192249
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8R491
• Gene Symbols: EHD3
• Immunogen: synthetic peptide directed towards the C-terminal region of rat EHD3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG