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Edicotinib, MedChemExpress

Product Code. 16493016
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Product Code. 16493016 Supplier Medchem Express Supplier No. HY109086

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Description

MedChemExpress Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM.

Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research.

Specifications

Chemical Name or Material Edicotinib
CAS 1142363-52-7
Color White
Purity Grade Notes Research
Molecular Formula C27H35N5O2
Quantity 25 mg
Synonym JNJ-40346527 JNJ-527
Solubility Information DMSO : 16.67 mg/mL (36.11 mM; Need ultrasonic)
SMILES O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2
Molecular Weight (g/mol) 461.6
Formula Weight 461.6
Percent Purity 98.14%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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