Invitrogen™ ECSIT Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA560183

Product Code. 15748021

Description

Immunogen sequence: HMEPDLSARV TIYQVPLPKD STGAADPPQP HIVGIQSPDQ QAALARHNPA RPVFVEGPFS LWLRNKCVYY HILRADLLPP EEREVEETPE EWNLYYPM Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.

Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Specifications

• Antigen: ECSIT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ECSIT
• Gene Alias: Ecsit; ECSIT homolog; ECSIT homolog (Drosophila); ECSIT signalling integrator; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved; Protein SITPEC; signaling intermediate in Toll pathway-evolutionarily conserved; Sitpec
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26940, 300447, 51295
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5XIC2, Q9BQ95, Q9QZH6
• Gene Symbols: ECSIT
• Immunogen: Recombinant protein corresponding to Human ECSIT. Recombinant protein control fragment (Product #RP-99074).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG