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E6AP Recombinant Rabbit Monoclonal Antibody (HL1660), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen MA547128
This item is not returnable.
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Description
Store as concentrated solution. Centrifuge briefly prior to opening vial.
UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. UBE3A also plays an important role in the regulation of the circadian clock. Defects in UBE3A are a cause of Angelman syndrome (AS).
Specifications
| E6AP | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative | |
| Q05086 | |
| UBE3A | |
| Recombinant protein encompassing a sequence within the center region of human UBE3A. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| Western Blot | |
| HL1660 | |
| Unconjugated | |
| UBE3A | |
| 4732496B02; 5830462N02Rik; A130086L21Rik; ANCR; AS; CTCL tumor antigen se37-2; E6AP; E6-AP; E6-AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HECT-type ubiquitin transferase E3A; HPVE6A; human papilloma virus E6-associated protein; human papillomavirus E6-associated protein; mKIAA4216; oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin conjugating enzyme E3A; ubiquitin protein ligase E3A; ubiquitin-protein ligase E3A | |
| Rabbit | |
| Protein A | |
| RUO | |
| 7337 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |