Invitrogen™ E2F3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584678

Product Code. 16391625

Description

Immunogen sequence: TNNQDHNGNI PKPASKDLAS TNSGHSDCSV SMGNLSPLAS PANLLQQTED QIPSNLEGPF VNLLPPLLQE DYLL Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Specifications

• Antigen: E2F3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: E2F3
• Gene Alias: DKFZp686C18211; E2F transcription factor 3; E2f3; E2F-3; E2f3a; E2F3b; KIAA0075; MGC104598; RGD1561600; RP1-177P22.2; Transcription factor E2F3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1871
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O00716
• Gene Symbols: E2F3
• Immunogen: Recombinant protein corresponding to Human E2F3. Recombinant protein control fragment (Product #RP-107394).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG