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E-64

Product Code. 15445229
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 15445229

Brand: Thermo Scientific Alfa Aesar J62933.#0

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Description

Selective and irreversible cysteine protease inhibitor | CAS: 66701-25-5 | C15H27N5O5 | 357.41 g/mol

It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

Solubility
Soluble in DMSO (25mg/ml), or water (20mg/ml)

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong acids, strong bases.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 66701-25-5
Molecular Formula C15H27N5O5
Molecular Weight (g/mol) 357.41
MDL Number MFCD00080261,MFCD00080261
InChI Key LTLYEAJONXGNFG-HBNTYKKESA-N
Synonym d09fgq, l-3-trans-carboxy-oxiran-2-carbonyl-leu-agmatin, trans-epoxysuccinyl-leucylamido-4-guanidino butane, 3-1-4-carbamimidamidobutyl carbamoyl-3-methylbutyl carbamoyl oxirane-2-carboxylic acid, 3-1-4-diaminomethylideneamino butylamino-4-methyl-1-oxopentan-2-yl carbamoyl oxirane-2-carboxylic acid
PubChem CID 4641099
IUPAC Name 3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
SMILES CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCN=C(N)N

Specifications

Color White
Quantity 5 mg
Beilstein 1405664
Sensitivity Light sensitive
Solubility Information Soluble in DMSO (25mg/ml), or water (20mg/ml)
Optical Rotation +24° (c=1 in 1N HCl)
Formula Weight 357.4
Physical Form Powder
Chemical Name or Material E-64

RUO – Research Use Only

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