Dystroglycan Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16807803	Proteintech 11017-1-AP-20UL	20 μL
16897793	Proteintech 11017-1-AP-150UL	150 μL

Description

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Specifications

• Antigen: Dystroglycan
• Applications: Immunoprecipitation, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Rat, Mouse
• Gene Accession No.: Q14118, Q62165
• Gene ID (Entrez): 114489, 13138, 1605
• Immunogen: Dystroglycan Fusion Protein Ag1456
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: DAG1

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: 156DAG, A3a, AGRNR, Alpha DG Beta dystroglycan, Beta DG, DAG, DAG1, Dystroglycan
• Gene Symbols: Dag1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody