Invitrogen™ DYNC1H1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5115149

Product Code. 17247913

Description

Antibody detects endogenous levels of total DYNC1H1.

DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.

Specifications

• Antigen: DYNC1H1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: dync1h1
• Gene Alias: 9930018I23Rik; AI894280; CMT2O; cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; cytoplasmic dynein heavy chain polypeptide 1; Dhc1; DHC1a; DNCH1; Dnchc1; DNCL; Dnec1; DNECL; DYHC; DYNC1H1; dynein cytoplasmic 1 heavy chain 1; dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; fk70a07; HL-3; KIAA0325; legs at odd angle; Loa; MAP 1C; MAP1C; mKIAA0325; p22; SMALED1; sprawling; Swl; wu:fk70a07
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13424, 1778, 29489
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P38650, Q14204, Q9JHU4
• Gene Symbols: dync1h1
• Immunogen: A synthesized peptide derived from human DYNC1H1(Accession Q14204), corresponding to amino acid residues S2082-P2132.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG