Dynactin 2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA530389

Product Code. 13414887

Description

Recommended positive controls: MCF-7. Predicted reactivity: Mouse (95%), Rat (96%), Xenopus laevis (80%), Chimpanzee (99%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.

Specifications

• Antigen: Dynactin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCTN2
• Gene Alias: 2310042E05Rik; 50 kDa dynein-associated polypeptide; C130077D06Rik; C87049; DCTN2; dctn2 protein; DCTN50; DCTN-50; dynactin 2; dynactin 2 (p50); dynactin complex 50 kDa subunit; Dynactin subunit 2; dynamitin; epididymis secretory protein Li 77; GMP23-48K; Growth cone membrane protein 23-48K; HEL-S-77; hypothetical protein LOC527201; p50; p50 dynamitin; p50/dynamitin; RBP50; zgc:63867
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10540
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q13561
• Gene Symbols: DCTN2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 253 of Human Dynactin 2
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG