DUT Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16822114	Proteintech 13740-1-AP-20UL	20 μL
16812114	Proteintech 13740-1-AP-150UL	150 μL

Description

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Specifications

• Antigen: DUT
• Applications: Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat, Human
• Gene Accession No.: P33316, P70583
• Gene ID (Entrez): 110074, 1854, 497778
• Immunogen: DUT Fusion Protein Ag4677
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: DUT

• Concentration: 0.39 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: deoxyuridine triphosphatase, DUT, dUTP pyrophosphatase, dUTPase
• Gene Symbols: DUT
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody