Invitrogen™ DUSP8 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA518007

Product Code. 11385973

Description

This antibody is predicted to react with bovine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Specifications

• Antigen: DUSP8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP8
• Gene Alias: 5530400B01Rik; AI593498; C11orf81; dual specificity phosphatase 8; dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; Dusp8; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; Hb5; HVH-5; HVH8; M3/6; neuronal tyrosine threonine phosphatase 1; neuronal tyrosine/threonine phosphatase 1; Nttp1; OTTHUMP00000164487; serine/threonine specific protein phosphatase; VH5
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 18218, 1850, 361679
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O09112, Q13202
• Gene Symbols: DUSP8
• Immunogen: Synthetic peptide sequence (AGDRLPRKVMDAK) corresponding to the N-terminus amino acids of DUSP8 (aa 2-14).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG