Invitrogen™ DUSP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA530438

Product Code. 13414937

Description

Recommended positive controls: A549, HeLa. Predicted reactivity: Mouse (87%), Rat (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Dual specificity phosphatase (DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.

Specifications

• Antigen: DUSP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dusp12
• Gene Alias: 1190004O14Rik; AA027408; AW049275; dual specificity phosphatase 12; dual specificity phosphatase T-DSP4; Dual specificity phosphatase VH1; dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; DUSP1; Dusp12; ESTM36; LMW-DSP4; mVH1; serine/threonine specific protein phosphatase; T-DSP4; VH1; YVH1; YVH1 protein-tyrosine phosphatase ortholog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11266
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.94 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9UNI6
• Gene Symbols: Dusp12
• Immunogen: Recombinant protein encompassing a sequence within the center region of human DUSP12. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG