Invitrogen™ DRG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA550398

Product Code. 15684325

Description

The antibody detects endogenous levels of total DRG1 protein.

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). [UniProt].

Specifications

• Antigen: DRG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DRG1
• Gene Alias: AA408859; AI132520; developmentally regulated GTP binding protein 1; developmentally regulated GTP-binding protein 1; developmentally-regulated GTP-binding protein 1; Drg; Drg1; DRG-1; GTP-binding protein; NEDD3; NEDD-3; neural precursor cell expressed developmentally down-regulated protein 3; neural precursor cell expressed, developmentally down-regulated 3; TRAFAC GTPase DRG1; Translation factor GTPase DRG1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13494, 4733
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P32233, Q9Y295
• Gene Symbols: DRG1
• Immunogen: Fusion protein corresponding to residues near the C terminal of human developmentally regulated GTP binding protein 1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG