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Invitrogen™ DREF Polyclonal Antibody

Product Code. 12848882
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Quantity:
100 μg
Unit Size:
100µg
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12848882 100 μg 100µg
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Product Code. 12848882 Supplier Invitrogen™ Supplier No. PA520732

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A549 cell lysate. PA5-20732 can be used with blocking peptide PEP-0846.

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DREF
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZBED1
Gene Accession No. O96006
Gene Alias Ac-like transposable element; ALTE; BED-type zinc finger domain-containing protein 1; DNA replication-related element binding factor; DREF; dREF homolog; hDREF; KIAA0785; Putative Ac-like transposable element; TRAMP; ZBED1; Zinc finger BED domain-containing protein 1; zinc finger BED-type containing 1; zinc finger, BED-type containing 1
Gene Symbols ZBED1
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the center of human ZBED1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9189
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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