Invitrogen™ DRAM Polyclonal Antibody

Rabbit Polyclonal Antibody

Marca:  Invitrogen™ PA520335

Codice prodotto. 12828522

Descrizione

A suggested positive control is 293 cell lysate. PA5-20335 can be used with blocking peptide PEP-0455.

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Specifica

• Antigen: DRAM
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DRAM1
• Gene Alias: 1200002N14Rik; Damage-regulated autophagy modulator; DNA damage regulated autophagy modulator 1; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; DRAM; Dram1; FLJ11259; hypothetical protein FLJ11259; zgc:101811
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55332, 679937, 71712
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8N682, Q9DC58
• Gene Symbols: DRAM1
• Immunogen: A 16 amino acid peptide from near the carboxy terminus of human DRAM.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG