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Invitrogen™ DRAM Polyclonal Antibody

Product Code. 12818522
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Quantity:
100 μg
Unit Size:
100µg
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12818522 100 μg 100µg
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Product Code. 12818522 Supplier Invitrogen™ Supplier No. PA520336

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Description

Rabbit Polyclonal Antibody

A suggested positive control is K562 cell lysate. PA5-20336 can be used with blocking peptide PEP-0456.

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DRAM
Applications Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene DRAM1
Gene Accession No. Q8N682, Q9DC58
Gene Alias 1200002N14Rik; Damage-regulated autophagy modulator; DNA damage regulated autophagy modulator 1; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; DRAM; Dram1; FLJ11259; hypothetical protein FLJ11259; zgc:101811
Gene Symbols DRAM1
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the amino terminus of human DRAM.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55332, 679937, 71712
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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