Invitrogen™ DRAK2 Polyclonal Antibody

Product Code.	Quantity	unitSize
12848142	100 μg	100µg

Product Code. 12848142 Supplier Invitrogen™ Supplier No. PA519927

Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~45kDa. A suggested positive control is Jurkat cell lysate. PA5-19927 can be used with blocking peptide PEP-0052.

STK17B (also known as DRAK2) is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis. STK17B is selectively important for T-cell survival and inhibition of STK17B has therapeutic potential for autoimmune disease. T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of STK17B can affect autoimmune disease susceptibility without generalized suppression of the immune system. Protein kinases play important roles in the signal transduction in response to a variety of external stimuli. Recently, several protein kinases have been identified that may also be involved in apoptotic process. Overexpression of a serine/threonine kinase, ZIP kinase can cause the morphological changes typical of apoptosis in NIH 3T3 cells. Sanjo et al, have identified two new protein kinases DRAK1 and DRAK2 (Death Receptor Associated Kinase 1 and 2). Both DRAKs and ZIP kinase share significant homology at the amino acid level. The kinase domains of both DRAKs, ZIP kinase are homologous to DAP (Death-associated protein) kinase, which is involved in the apoptotic signaling induced by interferon-g. Overexpression of DRAKs in NIH 3T3 cells lead to apoptosis. These transfection experiments suggest that C-terminal domain of DRAKs are important for induction of apoptosis.

Specifications

• Antigen: DRAK2
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: STK17B
• Gene Accession No.: O94768
• Gene Alias: 3110009A03Rik; AI120141; DAP kinase-related apoptosis-inducing protein kinase 2; death-associated protein kinase-related 2; DRAK 2; DRAK2; serine/threonine kinase 17b; serine/threonine kinase 17b (apoptosis-inducing); serine/threonine-protein kinase 17B; ST17B; STK 17B; Stk17b
• Gene Symbols: STK17B
• Host Species: Rabbit
• Immunogen: A peptide corresponding to amino acids 351 to 365 of human DRAK2.
• Purification Method: Ion-exchange chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9262
• Target Species: Human
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG