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Invitrogen™ DR4 Polyclonal Antibody

Product Code. 12848102
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12848102 100 μg 100µg
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Product Code. 12848102 Supplier Invitrogen™ Supplier No. PA519887

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. DR4 antibody has no cross reaction to DR5. The PA5-19887 immunogen is located within the first 50 amino acids of DR4. Predicted molecular ~ 50kD. In Western blot applications, this antibody has been observed to detect a band at: 55kD (Post-modification: 1 N-linked glycosylation).

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DR4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TNFRSF10A
Gene Accession No. O00220
Gene Alias APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
Gene Symbols TNFRSF10A
Host Species Rabbit
Immunogen A 20 amino acid peptide near the amino terminus of human DR4.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8797
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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