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Invitrogen™ DR4 Polyclonal Antibody

Product Code. 12848092
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Quantity:
100 μg
Unit Size:
100µg
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12848092 100 μg 100µg
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Product Code. 12848092 Supplier Invitrogen™ Supplier No. PA519876

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. PA5-19876 can be used with blocking peptide PEP-0011. DR4 antibody has no cross reaction to DR5 The PA5-19876 immunogen is located within the last 50 amino acids of DR4. Predicted molecular ~ 50kD. In Western blot applications, this antibody has been observed to detect a band at: 55kD (Post-modification: 1 N-linked glycosylation).

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DR4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TNFRSF10A
Gene Accession No. O00220
Gene Alias APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
Gene Symbols TNFRSF10A
Host Species Rabbit
Immunogen A 19 amino acid peptide near the carboxy terminus of human DR4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8797
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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