Invitrogen™ DPH5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584994

Product Code. 16331945

Description

Immunogen sequence: VLRATKLGIP YRVIHNASIM NAVGCCGLQL YKFGETVSIV FWTDTWRPES FFDKVKKNRQ NGMHTLCLLD IKVKEQSLEN LIKGRKIYEP PRYMS Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 94%.

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: DPH5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DPH5
• Gene Alias: AD-018; CGI-30; diphthamide biosynthesis 5; diphthamide biosynthesis methyltransferase; Diphthine methyl ester synthase; diphthine synthase; DPH5; DPH5 homolog; HSPC143; NPD015; protein x 0011
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51611
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H2P9
• Gene Symbols: DPH5
• Immunogen: Recombinant protein corresponding to Human DPH5. Recombinant protein control fragment (Product #RP-108077).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG