Doxycycline hydrochloride, Thermo Scientific™

Description

Doxycycline hydrochloride, CAS # 10592-13-9, is the hydrochloride salt form of doxycycline that shows antibacterial and antimalarial activities.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Doxycycline hydrochloride is a compound that shows antibacterial and antimicrobial activities against several species, including Pseudomonas aeruginosa, Plasmodium falciparum, and Escherichia coli. It is also a bacteriostatic

• It can block the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis

Application

• It is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and eliminate Ixodes scapularis ticks

• Doxycycline hydrochloride is also considered to be a broad-spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase, in wound healing and tissue remodeling studies. Due to this activity, it can inhibit angiogenesis and reduce lung metastases

Specifications

• CAS: 10592-13-9
• Molecular Formula: C22H25ClN2O8
• MDL Number: MFCD03427564
• Solubility Information: Soluble in water to 50mg/ml; May require warming.
• InChI Key: VLUQVUWDECWBTL-UQVCFKGQSA-N
• SMILES: [Cl-].C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H]([NH+](C)C)C(=O)\C(=C(/N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12
• IUPAC Name: (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
• Molecular Weight (g/mol): 480.90
• PubChem CID: 54706018
• Formula Weight: 480.9
• Color: Yellow
• Quantity: 25g
• Chemical Name or Material: Doxycycline hydrochloride

RUO – Research Use Only