STEMCELL Technologies Doxycycline (Hyclate)

Product Code. 17100122

Brand: STEMCELL Technologies 72742

Description

Antibiotic; Used in Tet-inducible gene expression systems

• Doxycycline is a tetracycline-like antibiotic (Hicks et al.; Nau et al.; Solís García del Pozo & Solera; Steinhardt et al.) In genetic engineering, doxycycline is used as the regulator for inducible gene expression systems, whereby expression depends on either the presence (Tet-On) or absence (Tet-Off ) of doxycycline
• Also, doxycycline inhibits certain matrix metalloproteinases (MMP), such as MMP-8 (Ki = 36 μM; Griffin et al.; Smith et al.) It only poorly inhibits MMP-1 and MMP-13 (Ki > 100 μM; Smith et al.) This product is supplied as the hyclate salt of the molecule
• Used as the regulator for inducible gene expression in lentiviral infection and transgenic mouse models using the Tet-On or Tet-Off systems (Brambrink et al.; Carey et al.; Haenebalcke et al.; Hanna et al.; Hockemeyer et al.; Maherali et al.; Markoulaki et al.; Stadtfeld et al. 2008, 2010; Wernig et al.)

Specifications

• CAS: 24390-14-5
• Synonym: WC 2031
• Quantity: 1 g
• Molecular Formula: 2[C₂₂H₂₄N₂O₈] · 2HCl · H₂O · C₂H₆O
• Purity: ≥98%