Doxorubicin hydrochloride, MedChemExpress

Product Code. 16452437

Brand: Medchem Express HY15142

Description

MedChemExpress Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent.

Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

Specifications

• Chemical Name or Material: Doxorubicin hydrochloride
• Physical Form: Solid
• CAS: 25316-40-9
• Color: Reddish Brown
• Quantity: 50 mg
• Purity Grade Notes: Research
• Molecular Formula: C₂₇H₃₀ClNO₁₁
• For Use With (Application): Cancer-Kinase/protease
• Synonym: Hydroxydaunorubicin hydrochloride
• Solubility Information: DMSO : 35.71 mg/mL (61.57 mM; ultrasonic and warming and heat to 60°C) ∣H2O : 20 mg/mL (34.48 mM; Need ultrasonic)
• SMILES: COC1=C2C(C(C(C(O)=C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@@]4([H])C[C@H](N)[C@H](O)[C@H](C)O4)C3=C5O)=C5C2=O)=O)=CC=C1.[H]Cl
• Molecular Weight (g/mol): 579.98
• Formula Weight: 579.98
• Percent Purity: 95.0%
• Grade: Research

Safety and Handling

Product Identifier

• Doxorubicin (hydrochloride)

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Carcinogenicity Category 1A
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H350-May cause cancer.

Precautionary Statement

• P201-Obtain special instructions before use.
• P202-Do not handle until all safety precautions have been read and understood.
• P264-Wash hands thoroughly after handling.
• P270-Do not eat, drink or smoke when using this product.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P313-Get medical advice/attention.
• P321-Specific treatment (see on this label).
• P330-Rinse mouth.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.
• P362-Take off contaminated clothing.
• P405-Store locked up.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Hydroxydaunorubicin(hydrochloride)

Research purposes only