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Invitrogen™ Doublecortin Polyclonal Antibody
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Product Code. 17818412
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Quantity:
100 μg
Unit Size:
100µL
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Product Code. Quantity unitSize
17818412 100 μg 100µL
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Product Code. 17818412 Supplier Invitrogen™ Supplier No. PA5142703

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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognize all four reported isoforms (NP_000546.2; NP_835365.1; NP_835364.1; NP_001182482.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
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Specifications

Antigen Doublecortin
Applications Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene DCX
Gene Accession No. O43602, Q9ESI7
Gene Alias DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
Gene Symbols DCX
Host Species Goat
Immunogen Peptide with sequence C-KTSANMKAPQS (aa 151-161).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1641, 84394
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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