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  5. Tocris Bioscience™ Dorsomorphin dihydrochloride

Tocris Bioscience™ Dorsomorphin dihydrochloride

Product Code. 18055202
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50 mg
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18055202 50 mg 50mg
18054882 10 mg 10mg
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Product Code. 18055202 Supplier Tocris Bioscience™ Supplier No. 3093/50

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708.90 GBP valid until 2026-03-31
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Description

Potent AMPK inhibitor

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1219168-18-9
Molecular Formula C24H27Cl2N5O

Specifications

Quantity 50 mg
Formula Weight 472.41
Purity >98%
Molecular Weight (g/mol) 472.414
Chemical Name or Material Dorsomorphin dihydrochloride
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