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Dolutegravir, MedChemExpress

Product Code. 16491066
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Product Code. 16491066

Brand: Medchem Express HY13238

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Description

MedChemExpress Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).

Specifications

Chemical Name or Material Dolutegravir
Physical Form Solid
CAS 1051375-16-6
Color White
Quantity 200 mg
Purity Grade Notes Research
Molecular Formula C20H19F2N3O5
For Use With (Application) COVID-19-anti-virus
Synonym S/GSK1349572
Solubility Information DMSO : 10 mg/mL (23.84 mM; Need ultrasonic and warming)
SMILES FC1=CC(F)=C(C=C1)CNC(C2=CN(C3=C(C2=O)O)C[C@@]([H])(N4C3=O)OCC[C@H]4C)=O
Molecular Weight (g/mol) 419.38
Formula Weight 419.38
Percent Purity 98.76%
Grade Research
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Research purposes only

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