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Invitrogen™ DOK1 Polyclonal Antibody
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Product Code. 16643805
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Quantity:
100 μL
Unit Size:
100µL
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16643805 100 μL 100µL
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Product Code. 16643805 Supplier Invitrogen™ Supplier No. PA599555

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total p62 Dok.

DOK1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOK1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DOK1
Gene Accession No. P97465, Q4QQV2, Q99704
Gene Alias AW557123; Docking protein 1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); Dok; DOK 1; DOK1; Dok-1; Downstream of tyrosine kinase 1; downstream of tyrosine kinase-1; MGC117395; MGC138860; p240; p62 dok; p62(dok); p62DOK; pp62; TLP1; TP1; TROVE domain family; TROVE1; VAULT2
Gene Symbols DOK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human DOK1(Accession Q99704), corresponding to amino acid residues P372-A422.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13448, 1796, 312477
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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