Gibco™ Dog MRP2 Vesicles

Código de producto.	Quantity	unitSize
10734321	0.5 mL	Each

Código de producto. 10734321

missing translation for 'mfr': Gibco™ GM0014

Descripción

Dog MRP2 Vesicles are insect derived purified plasma membranes with inserted MRP2 transport protein (multidrug resistance-associated protein, ABCC2).

Dog MRP2 Vesicles are insect derived purified plasma membranes with inserted MRP2 transport protein (multidrug resistance-associated protein, ABCC2). Our Dog MRP2 Vesicles can be used to evaluate test compounds and drug interactions with MRP2 in in vitro assays. MRP2 is an ATP-binding cassette (ABC) transporter that carries organic anions.

Use Dog MRP2 Vesicles to:

• Investigate the transporter interactions of your drug candidates
• Assess potential for transporter-mediated drug-drug interactions
• Obtain high quality results with a large signal to noise ratios

Concept Behind ABC Transporter Vesicles

ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate's substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.

Clear and Reliable Results

Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these 'inside-out' vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.

Transporter Vesicle Details

Dog MRP2 Vesicles are part of a larger group of transporter vesicles known as ABC transporter vesicles. They are prepared from purified plasma membranes isolated from an insect cell system (Sf9 cells transfected with baculovirus) expressing MRP2. MRP2 is expressed in various organs, and is thought to play a role in excretion of various compounds from the kidney and liver, based on its localization on the canalicular plasma membrane of hepatocytes and brush border membrane of tubular epithelial cells.

Especificaciones

• Physical Form: Frozen
• Grade: Research Grade
• For Use With (Application): Pharma and Biopharma
• Quantity: 0.5 mL
• Packaging: Vial
• Purity: Research Grade
• Content And Storage: -80°C, Store at -80°C.
• Host Species: Canine
• Product Type: Dog Vesicle, Dog MRP2 Vesicles
• Format: Vial
• Shipping Condition: Dry Ice
• Source: Insect derived purified plasma membranes with inserted MRP2 transport protein (multidrug resistance-associated protein, ABCC2)
• Form: Frozen

For Research Use Only. Not for use in diagnostic procedures.