Invitrogen™ DOCK3 Polyclonal Antibody

Sheep Polyclonal Antibody

Brand:  Invitrogen™ PA547902

Product Code. 15568392

Description

In direct ELISAs, less than 3% cross-reactivity with recombinant human (rh) DOCK1, rhDOCK2, and rhDOCK5 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.

Specifications

• Antigen: DOCK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dock3
• Gene Alias: dedicator of cytokinesis 3; dedicator of cyto-kinesis 3; dedicator of cytokinesis protein 3; DOCK3; dok-3; KIAA0299; mKIAA0299; MOCA; Modifier of cell adhesion; PBP; Presenilin-binding protein
• Host Species: Sheep
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1795
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8IZD9
• Gene Symbols: Dock3
• Immunogen: E. coli-derived recombinant human DOCK3 Gly418-Thr656.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG