Invitrogen™ DOCK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557996

Product Code. 15705891

Description

Immunogen sequence: FEVVDSDQIS VSDLYKMHLS SRQSVQQSTS QVDTMRPRHG ETCRMPVPHH FFLSLKSFTY NTIGEDTDVF FSLYDMREGK QISERFLVRL NKNG Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.

Specifications

• Antigen: DOCK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dock3
• Gene Alias: dedicator of cytokinesis 3; dedicator of cyto-kinesis 3; dedicator of cytokinesis protein 3; DOCK3; dok-3; KIAA0299; mKIAA0299; MOCA; Modifier of cell adhesion; PBP; Presenilin-binding protein
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1795
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IZD9
• Gene Symbols: Dock3
• Immunogen: Recombinant protein corresponding to Human DOCK3. Recombinant protein control fragment (Product #RP-96295).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG