Docetaxel, 99%

Código de producto.	Quantity	missing translation for 'unitSize'
15462989	100 mg	100mg
15472989	500 mg	500mg
15452989	1 g	1g

Código de producto. 15462989 missing translation for 'mfr' Thermo Scientific Alfa Aesar missing translation for 'supplierNo' J60174.MC

Descripción

Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities. | CAS: 114977-28-5 | C43H53NO14 | 807.89 g/mol

Docetaxel is a second-generation cytotoxic antimicrotubule agent and is mostly used in the pharmaceutical industry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death

Application

• Docetaxel can inhibit angiogenesis by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells

Especificaciones

Identificadores de productos químicos

• CAS: 114977-28-5
• Molecular Formula: C43H53NO14
• Molecular Weight (g/mol): 807.89
• MDL Number: MFCD00800737
• InChI Key: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
• Synonym: docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl
• PubChem CID: 148124
• ChEBI: CHEBI:4672
• SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

• Melting Point: 186°C to 192°C
• Color: White
• Quantity: 100 mg
• Merck Index: 14,3397
• Solubility Information: Soluble in dimethyl sulfoxide and ethanol; Insoluble in water.
• Formula Weight: 807.88
• Percent Purity: 99%
• Physical Form: Powder
• Chemical Name or Material: Docetaxel

Seguridad y manipulación

SDS

RUO – Research Use Only