Dobutamine hydrochloride

Product Code.	Quantity	Unit Size
15453939	1 g	1g

Product Code. 15453939 Supplier Thermo Scientific Alfa Aesar Supplier No. J61333.03

Description

CAS: 49745-95-1 | C18H24ClNO3 | 337.84 g/mol

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1M.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 μM.

Solubility
Soluble in water or ethanol with warming. Also soluble in methanol

Notes
Solutions oxidize readily at pH greater than 11. Protect solutions from light

Specifications

Chemical Identifiers

• CAS: 49745-95-1
• Molecular Formula: C18H24ClNO3
• Molecular Weight (g/mol): 337.84
• MDL Number: MFCD00153795
• InChI Key: BQKADKWNRWCIJL-UHFFFAOYNA-N
• Synonym: dobutamine hydrochloride, dobutamine hcl, dobutrex, inotrex, dl-dobutamine hydrochloride, dobutamina clorhidrato spanish, 4-2-4-4-hydroxyphenyl butan-2-ylamino ethyl benzene-1,2-diol hydrochloride, +--4-2-3-p-hydroxyphenyl-1-methylpropyl amino ethyl pyrocatechol hydrochloride, 1,2-benzenediol, 4-2-3-4-hydroxyphenyl-1-methylpropyl amino ethyl-, hydrochloride, +-
• PubChem CID: 65324
• ChEBI: CHEBI:4671
• IUPAC Name: hydrogen 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol chloride
• SMILES: [H+].[Cl-].CC(CCC1=CC=C(O)C=C1)NCCC1=CC=C(O)C(O)=C1

• Melting Point: 184°C to 186°C
• Color: White
• Quantity: 1 g
• Merck Index: 14,3395
• Solubility Information: Soluble in water or ethanol with warming; Also soluble in methanol
• Formula Weight: 337.85
• Physical Form: Powder
• Chemical Name or Material: Dobutamine hydrochloride

Safety and Handling

Product Identifier

• Dobutamine hydrochloride

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Reproductive toxicity Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H312-Harmful in contact with skin.
• H332-Harmful if inhaled.
• H361-Suspected of damaging fertility or the unborn child.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contain: Dobutamine hydrochloride

SDS

RUO – Research Use Only