Invitrogen™ DNMBP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA566148

Product Code. 15998864

Description

Immunogen sequence: GVEWEMPLATD SPTSDPTEVV NGISSQPQVP FHPNLQKSQY YSTVGGSHPH SEQYPDLLPL EARTRDYASL PPKRMYSQL Highest antigen sequence identity to the following orthologs - mouse 63%, rat 51%.

The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.

Specifications

• Antigen: DNMBP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DNMBP
• Gene Alias: 2410003L07Rik; 2410003M15Rik; ARHGEF36; Dnmbp; dynamin binding protein; dynamin-binding protein; Kiaa1010; Scaffold protein Tuba; TUBA
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23268
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6XZF7
• Gene Symbols: DNMBP
• Immunogen: Recombinant Human DNMBP. Recombinant protein control fragment (Product #RP-106830).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG