DNAL1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520573

Product Code. 12828752

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20573 can be used with blocking peptide PEP-0693.

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

Specifications

• Antigen: DNAL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dnal1
• Gene Alias: 1700010H15Rik; AW121714; axonemal dynein light chain 1; C14orf168; CILD16; DNAL1; Dnalc1; dynein axonemal light chain 1; dynein light chain 1, axonemal; dynein, axonemal, light chain 1; E330027P08Rik; LC1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105000, 685664, 83544
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q05A62, Q4LDG9
• Gene Symbols: Dnal1
• Immunogen: A 17 amino acid peptide from near the carboxy terminus of human DNAL1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG