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Invitrogen™ DNA-PK Monoclonal Antibody (3H6)

Product Code. 12847832
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
12847832 100 μL 100µL
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Product Code. 12847832 Supplier Invitrogen™ Supplier No. MA515813

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Description

Mouse Monoclonal Antibody

MA5-15813 targets PRKDC in indirect ELISA, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-15813 immunogen is purified recombinant fragment of human PRKDC expressed in E. Coli. MA5-15813 detects PRKDC which has a predicted molecular weight of approximately 46.9kDa.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNA-PK
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3H6
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene PRKDC
Gene Accession No. P78527
Gene Alias AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Gene Symbols PRKDC
Host Species Mouse
Immunogen Purified recombinant fragment of human PRKDC expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5591
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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